EVALUATION OF TRANSDERMAL TRANSPORT AND CONCURRENT CUTANEOUS HYDROLYSIS OF TIMOLOL PRODRUG FOR THE TREATMENT OF INFANTILE HEMANGIOMAS

Evaluation of Transdermal Transport and Concurrent Cutaneous Hydrolysis of Timolol Prodrug for the Treatment of Infantile Hemangiomas

Infantile hemangiomas (IH) leave sequelae after involution.Topical application of timolol maleate (TM) is the mainstream treatment for superficial lesions but is limited by its low penetrable properties.We aimed to develop a superior skin permeation drug while maintaining the therapeutic properties of timolol.We predict that this drug will promote

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Sisters with no pain, no tears: A report of a new variant of hereditary sensory and autonomic neuropathy (Type IX) Caused by a novel SCN11A mutation

Lack of pain sensation in children involves a rare group of heritable disorders; hereditary sensory and autonomic neuropathy (HSAN).Till date, eight types of Refrigeration Gas Adaptor HSAN have been described depending on the clinical phenotype and the underlying gene mutation.We report a new variant of HSAN (Type IX) in two siblings (of Indian ori

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